Introduction of Endoxan N 500 mg Injection

• Endoxan N 500 mg Injection is an anticancer medicine used for the treatment of various types of malignant diseases such as malignant lymphomas, Hodgkin’s disease, lymphocytic lymphoma, mixed-cell type lymphoma, histiocytic lymphoma, Burkitt’s lymphoma, multiple myeloma, leukaemias, mycosis, fungicides, neuroblastoma, adenocarcinoma of the ovary, retinoblastoma, breast carcinoma, etc. Endoxan N 500 mg Injection is also used to treat kidney disease known as a nephrotic syndrome in children after other treatments have not worked. It may be also used to treat other conditions, as determined by the doctor. Endoxan N 500 mg Injection works by slowing or stopping the growth of cancer cells in your body. When Endoxan N 500 mg Injection is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

  Endoxan N 500 mg Injection is not recommended for use in patients suffering from urine outflow obstruction disease, and patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the Endoxan N 500 mg Injection. Endoxan N 500 mg Injection may cause nausea, vomiting, stomatitis (inflamed and sore mouth), weakness, malaise (general discomfort), fever, leukopenia (low white blood cell count), and alopecia (hair loss). You are advised to talk to your doctor if the side effects persist or worsen. It is a very strong medicine and some people may develop serious side effects while taking it. Endoxan N 500 mg Injection may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well.

  Before using Endoxan N 500 mg Injection, tell your doctor if you have liver, or kidney problems or any other health complications. Additionally, inform if you are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. Endoxan N 500 mg Injection is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy

  Endoxan N 500 mg Injection is administered by a doctor or nurse at a hospital or clinical setting. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change occasionally. You should take it exactly as your doctor has advised. Taking it the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid smoking and drinking alcohol as it may increase the risk of liver damage. Do not self-administered this Endoxan N 500 mg Injection.

Uses of Endoxan N 500 mg Injection

• • Hodgkin's lymphoma
    
  • Non-Hodgkin's lymphoma
  • Cutaneous T cell lymphoma (CTCL)
  • Acute myeloid leukaemia (AML)
  • Multiple myeloma
  • Chronic lymphocytic leukaemia (CLL)
  • Acute lymphoblastic leukaemia (ALL)
  • Retinoblastoma
  • Neuroblastomas
  • Ovarian cancer
  • Nephrotic syndrome
  • Chronic myelogenous leukaemia (CML)

Benefits of Endoxan N 500 mg Injection

• ​​Endoxan N 500 mg Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Endoxan N 500 mg works by stopping or slowing the growth of cancer cells in the body. Thereby, Endoxan N 500 mg helps treat cancer. Additionally, Endoxan N 500 mg Injection is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Endoxan N 500 mg Injection suppresses the body's immune system, thereby helping treat nephrotic syndrome.​​

Side Effects of Endoxan N 500 mg Injection

• ​Endoxan N 500 mg Injection may cause some side effects. If you experience any of these side effects contact your doctor as soon as possible. Your doctor may be able to suggest ways to manage or reduce the severity of these side effects.

Most Common Side Effects of Endoxan N 500 mg Injection

• • Bruising
  • Bleeding
  • Slow healing existing wounds
  • Mouth sores
  • Tiredness
  • Decrease in the amount of urine
  • Weakness

Common Side Effects of Endoxan N 500 mg Injection

• • Leukopenia
    
  • Bladder bleeding
  • Serious Injection
  • Infertility
  • ​Nausea and vomiting
  • Bone marrow suppression
  • Hemorrhagic cystitis
  • Stomach ache
  • Darkening of the nails/skin
  • Diarrhoea
  • Thinning of hair
  • Alopecia (Hair Loss)
  • Change in texture and colour of the hair
  • Profound gonadotoxicity
  • Lethargy

How to Use Endoxan N 500 mg Injection?

• ​​Endoxan N 500 mg Injection is administered intravenously (into a vein) by a health care professional, nurse or doctor in a medical facility. The frequency and dosage of Endoxan N 500 mg Injection injection is decided by your health care professional or doctor. You should inform your health care, professional or doctor if you face any serious side effects. Do not self-administer Endoxan N 500 mg.​​

How Endoxan N 500 mg Injection Works?

• ​​Endoxan N 500 mg Injection contain an active ingredient called cyclophosphamide, which is an alkylating agent used in the treatment of cancer and certain autoimmune disorders. Endoxan N 500 mg Injection acts by forming covalent bonds with DNA strands in rapidly dividing cells, including cancer cells. This process leads to the cross-linking of DNA strands, which interferes with their replication and transcription. Ultimately, the DNA damage caused by cyclophosphamide prevents cancer cells from growing and dividing. Additionally, Endoxan N 500 mg Injection has immunosuppressive properties, which can be beneficial in certain autoimmune disorders. Endoxan N 500 mg Injection suppresses the activity of the immune system by affecting lymphocytes, a type of white blood cell involved in immune responses. This immunosuppressive effect helps to reduce the overactive immune response associated with autoimmune conditions.​

Safety Advices Endoxan N 500 mg Injection

Pregnancy

Unsafe

Use of Endoxan N 500 mg Injection may be unsafe during pregnancy as limited animal studies indicate that it may harm the developing foetus. However, if you are pregnant or planning to become pregnant, it is important to talk to your doctor about the potential risks and benefits of taking Endoxan N 500 mg during pregnancy. Your doctor will be able to help you make the best decision for you and your baby's health.

Liver

Use with Caution

Endoxan N 500 mg Injection should be used with caution in patients with liver disease. It is important that patients with liver disease closely monitor liver function while taking Endoxan N 500 mg and report any unusual symptoms or changes in liver function to their doctor. The dose of Endoxan N 500 mg may need to be adjusted in patients with liver disease.

Breastfeeding

Unsafe

It is not recommended to breastfeed while taking Endoxan N 500 mg. Endoxan N 500 mg Injection may pass into breast milk and harm the infant. If you are breastfeeding and taking Endoxan N 500 mg, it is important to talk to your doctor about the possible risks and benefits of continuing to breastfeed. Your doctor will be able to help you make the best decision for you and your baby's health.

Kidney

Use with Caution

Endoxan N 500 mg Injection should be used with caution in patients with Kidney disease. It is important that patients with kidney disease closely monitor kidney function while taking Endoxan N 500 mg and report any unusual symptoms or changes in kidney function to their doctor. The dose of Endoxan N 500 mg may need to be adjusted in patients with kidney disease.

Alcohol

Unsafe

It is generally not recommended to drink alcohol while taking Endoxan N 500 mg Injection. It may increase the risk of liver damage. It is best to avoid alcohol or limit your alcohol consumption while taking any medication.

Driving

Unsafe

Endoxan N 500 mg Injection may cause dizziness, fatigue, and difficulty concentrating and coordinating, which may affect your ability to drive a vehicle safely. It is important to follow your doctor's instructions and take necessary precautions such as avoiding driving a vehicle or operating heavy machinery if you suffer from the side effects of this Endoxan N 500 mg.