Paclicad N Injection | 100 mg in 1 Vial

Introduction of Paclicad N Injection

Paclicad N Injection is a microtubule inhibitor that's used to treat metastatic breast cancer in patients who have failed combination chemotherapy or relapsed within 6 months of adjuvant chemotherapy. Paclicad N Injection can be combined with carboplatin as a first-line treatment for locally advanced or metastatic non-small cell lung cancer in patients who cannot undergo radical surgery or radiation therapy. Paclicad N Injection is used in combination with gemcitabine as the first-line therapy for metastatic pancreatic cancer. Prior therapy should include anthracyclines unless clinically contraindicated.

Use of Paclicad N Injection may cause common side effects such as alopecia, neutropenia, sensory neuropathy, ECG abnormalities, fatigue/weakness, muscle/joint pain, elevated AST, elevated alkaline phosphatase, anaemia, nausea, infections, diarrhoea, and thrombocytopenia. Your doctor may recommend additional medications to help manage these side effects. If you experience unexplained bruising or bleeding, a sore throat, mouth sores, or high fever, it is important that you tell your doctor right away. 

Paclicad N Injection can decrease the number of blood cells in your body, which can make you more susceptible to infections. Regular blood tests are essential for monitoring blood cell counts and liver function.

Patients with baseline neutrophil count below 1,500 cells/mm3 or a known allergy to Paclicad N Injection or any of its ingredients should avoid using Paclicad N Injection. It is important to note that the safety and effectiveness of this Paclicad N Injection have not been established in pediatric patients.

Before Taking Paclicad N Injection, it is important to inform your doctor of any pre-existing heart disease, liver or kidney problems, or current use of medications to treat infections. This Paclicad N Injection may interact with many other drugs or may affect their effectiveness, therefore it is important to disclose all medications you are taking to your doctor. Paclicad N Injection is not recommended to take this during pregnancy or while breastfeeding. It is crucial for both males and females to use effective contraception during treatment to prevent pregnancy.

Paclicad N Injection should be administered by a qualified healthcare professional in a hospital or clinic setting. Your doctor will determine the appropriate dosage and duration of therapy based on your clinical condition. It is important to complete the entire treatment course as prescribed, even if you begin to feel better before the therapy is completed. It may take several weeks or months to observe any improvement in your condition.

Uses of Paclicad N Injection

Metastatic Breast Cancer: Paclicad N Injection is used in the treatment of metastatic breast cancer is a type of breast cancer that has spread to other parts of the body, such as the bones, liver, lungs, or brain.

Non-Small Cell Lung Cancer (NSCLC): Paclicad N Injection is used in the treatment of Non-Small Cell Lung Cancer, which is a type of lung cancer that begins in the tissues of the lung and may spread to other parts of the body. Symptoms of NSCLC may include coughing, chest pain, shortness of breath, hoarseness, weight loss, and fatigue.

Ovarian Cancer: Paclicad N Injection is used in the treatment of ovarian cancer is a type of cancer that begins in the ovaries, which are part of the female reproductive system. It is often referred to as the "silent killer" because it often has no symptoms in the early stages, or the symptoms may be vague and easily attributed to other conditions. As cancer progresses, symptoms may include bloating, abdominal or pelvic pain, changes in bowel or bladder habits, and feeling full quickly when eating.

Pancreatic Adenocarcinoma: Paclicad N Injection is used in the treatment of pancreatic adenocarcinoma is a type of cancer that starts in the glandular cells of the pancreas, and its symptoms may not appear until the cancer is in an advanced stage. These symptoms may include abdominal pain, jaundice, weight loss, loss of appetite, nausea, and vomiting.

Benefits of Paclicad N Injection

Paclicad N Injection is an anticancer medicine that is used to treat many types of cancer, which include breast cancer, lung cancer, ovarian cancer, and pancreatic cancer.it's known to be efficient in treating different types of cancer either alone or in a mixture with other chemotherapy medications or radiation therapy. Paclicad N Injection interfering with the division of cancer cells, kills or stops the growth of cancer cells and prevents the multiplication of cancer cells and relieves the symptoms of breast cancer and stomach cancer. Paclicad N Injection can improve overall survival and disease-free survival in patients with HER2-positive breast cancer when used in combination with other cancer treatments.

Side Effects of Paclicad N Injection

​​​​Like all medications, Paclicad N Injection can cause side effects but do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Most Common Side Effects of Paclicad N Injection

• Hair loss
• Peripheral neuropathy
• Abnormal ECG
• Low blood count
• Nausea
• Vomiting
• Diarrhoea
• Loss of appetite
• Arthralgia ( joint pain)
• Myalgia (muscle pain)
• Mouth sores
• Headache

Common Side Effects of Paclicad N Injection

• Irregular Heartbeats ( Tachycardia/Bradycardia)
• Vision changes
• Bleeding
• ​Dizziness
• Vision changes​
  

How to Use Paclicad N Injection?

​Paclicad N Injection is an intravenous infusion, administered by a healthcare professional or nurse in a hospital or clinic setting. The specific dosing and administration of the Paclicad N Injection will be determined by the patient's clinical condition, age, medical history, type of cancer and other factors. It is important to note that this Paclicad N Injection should not be self-administered, and it is important to follow the instructions of the healthcare professional administering the Paclicad N Injection.

How Paclicad N Injection Works?

Paclicad N Injection acts by preventing mitosis. (mitosis is a process of cell division) it will prevent cell division. Paclicad N Injection will help the cellular structure, which helps move chromosomes during mitosis microtubules and to stop mitosis consequently, it will block the growth of cancer cells.

Safety Advices Paclicad N Injection

Liver

Use with Caution

Alcohol

Unsafe

Kidney

Safe

Breastfeeding

Unsafe

Driving

Unsafe

Pregnancy

Unsafe

References

1. Paclitaxel Protein-bound Particles For Injectable Suspension (albumin-bound), For Intravenous Use, Twi Usa - Twi Pharmaceuticals Usa, Inc. Product Leaflet 

2. Abraxane, For Injectable Suspension (paclitaxel Protein-bound Particles For Injectable Suspension) (albumin-bound), Celgene Corporation, Product Monograph 

3. Abraxane (nanoparticle Albumin-bound Paclitaxel), Abraxis Bioscience Australia Pty Ltd, [date Of Revision 02 April 2020 ], Product Leaflet 

4. Abraxane Nanoparticle Albumin-bound Paclitaxel 100 Mg Powder For Injection (suspension), Abraxis Bioscience Australia Pty Ltd, Avaliable From 

5. Abraxane 5 Mg/ml Powder For Suspension For Infusion, Celgene Europe Limited, Product Leaflet 

6. Prabraxane For Injectable Suspension, Celgene Inc, Product Monograph