Introduction of Celstemx 24 mg Injection

• Celstemx 24 mg Injection is a stem cell mobiliser indicated for use in combination with granulocyte colony-stimulating factor (G-CSF) to prepare haematopoietic stem cells for transplantation in patients with non-Hodgkin's lymphoma (a blood cancer that affects the lymphatic system) and multiple myeloma (a type of cancer that affects the plasma cells of the bone marrow).

  Celstemx 24 mg Injection contains Plerixafor, which belongs to the class of drugs called haematopoietic stem cell mobilisers. Celstemx Injection works by binding to the chemokine receptor CXCR4 and inhibiting the binding of its cognate ligand CXCL12.

  Celstemx 24 mg Injection may cause side effects like nausea, vomiting, headache, dizziness, diarrhoea, flatulence, tiredness, and injection site pain. These side effects will gradually disappear over time and do not require medical attention. This Celstemx Injection is for use by a healthcare professional who has training in the use of this medicine. It should never be administered by yourself.

  Do not use and tell your doctor if you are allergic to Celstemx Injection or any of its components. Tell your doctor before using if you have liver/kidney disease, heart disease, blood disorders, or respiratory problems. In pregnant women, this Celstemx Injection is known to cause fetal harm. Tell your doctor or health care professional if you are pregnant or plan to become pregnant. Breastfeeding should be avoided while on this Celstemx Injection.
  

Uses of Celstemx 24 mg Injection

• • Autologous stem cell transplant
    

Benefits of Celstemx 24 mg Injection

• Autologous stem cell transplant: This is a procedure in which certain blood cells are removed from the body and then returned to the body after chemotherapy and/or radiation in people with positive cancers. A doctor or nurse will give you this Celstemx 24 mg Injection. You should follow your doctor's instructions carefully to get the most benefit from it.
  

Side Effects of Celstemx 24 mg Injection

• Side effects, which are unwanted symptoms, can be caused by taking medicines. It is important to understand that all medicines have the potential to cause side effects. However, they may not affect everyone who takes them.
  

Most Common Side Effects of Celstemx 24 mg Injection

• • Constipation
  • Nausea
  • Dry mouth
  • Numbness
  • Stomach upset
  • Bloating
  • Lethargic
  • Muscle pain
  • Profuse perspiration
  • Rashes
    

Common Side Effects of Celstemx 24 mg Injection

• • Bleeding
  • Unusual weakness
  • Severe epigastric pain
  • Joint pain
  • Dizziness
  • ​Burning
  • Crawling
  • Itching
  • Vomiting
  • Headache
    

How to Use Celstemx 24 mg Injection?

• Celstemx 24 mg Injection is available in an injectable form. Celstemx Injection is given under the skin (subcutaneously) only under medical supervision and as directed by your doctor. Celstemx Injection is usually given 11 hours before the filtration of the blood. The dose and frequency will be determined by your doctor. It will depend on your medical condition, weight and certain other factors.
  

How Celstemx 24 mg Injection Works?

• Celstemx 24 mg Injection works by preventing the binding of cell-derived factors to the chemokine receptor (CXCR4) and the aggregation of cells in the bone marrow. This process releases stem cells into the bloodstream where they can be collected, isolated and stored for transplant.

Safety Advices Celstemx 24 mg Injection

Pregnancy

Unsafe

Celstemx 24 mg Injection should not be used during pregnancy. There is strong evidence of a risk to the developing baby. However, it may be prescribed by your doctor in rare, life-threatening situations where the benefits of use outweigh the potential risks.

Breastfeeding

Unsafe

Celstemx 24 mg Injection may be dangerous to use for the duration of breastfeeding. Limited human statistics show that the drug may also pass into breast milk and harm the baby.

Alcohol

Not known

The safety of the use of alcohol with Celstemx Injection is not known. It is advisable to have a discussion with your doctor about this.

Driving

Not known

The effect of Celstemx Injection on the ability to drive a vehicle has not been established. You should not drive if you experience symptoms that impair your concentration and reactions.

Kidney

Use with Caution

Celstemx 24 mg Injection must be used with a warning for patients with kidney disease. It may be necessary to adjust the dose of the injection. It is advisable to consult your doctor for further advice.

Liver

Use with Caution

Celstemx 24 mg Injection must be used with a warning for patients with liver disease. It may be necessary to adjust the dose of the injection. It is advisable to consult your doctor for further advice.