Introduction of Endoxan N 1000 mg Injection

• Endoxan N 1000 mg Injection is an anti-cancer medicine used to treat various types of malignant diseases including malignant lymphoma, Hodgkin's disease, lymphocytic lymphoma, mixed cell lymphoma, histiocytic lymphoma, Burkitt's lymphoma, multiple myeloma, leukaemia, mycosis, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, breast cancer, etc. It is also used to treat kidney disease called nephrotic syndrome in children after other treatments fail. It may also be used for the treatment of other conditions as determined by the doctor or nurse. Endoxan N 1000 mg Injection works by slowing or stopping cancer cells from growing in your body. When Endoxan N 1000 mg Injection is used for the treatment of nephrotic syndrome, it works by suppressing your body's immune system.
  
  Endoxan N 1000 mg Injection is not recommended for use in patients with urinary tract obstruction and in patients with a history of severe hypersensitivity to it, any of its metabolites, or other components of Endoxan N 1000 mg Injection. Endoxan N 1000 mg Injection may cause nausea, vomiting, stomatitis (mouth inflammation and pain), weakness, malaise (general feeling of being unwell), fever, leucopenia (low white blood cell count), and alopecia (hair loss). If these side effects persist or get worse, you should talk to your doctor or health care professional. This is a very strong medicine. Some people may develop serious side effects while taking this medicine. It can lower your ability to fight infections and cause problems with your blood, liver or kidneys. Your doctor or health care professional will advise you to have regular blood checks for these conditions. It is recommended that you drink extra fluids so that you pass more urine. This will help prevent bladder problems and keep your kidneys working.
  
  Tell your doctor if you have liver or kidney problems or any other health complications before using Endoxan N 1000 mg Injection. You should also tell your doctor if you are taking any medicines for the treatment of infections. This medicine may interact with, or be affected by many other medicines. Tell your doctor or health care professional about all the medicines you are taking. During pregnancy and while breastfeeding Endoxan N 1000 mg is not recommended. To avoid pregnancy it is important that both men and women use effective contraception during treatment.
  
  Endoxan N 1000 mg is given by a doctor or nurse in a hospital or clinic. The dose you need and how often you need to take it will be decided by your doctor. This depends on what you are being treated for and may change from time to time. Take exactly as directed by your doctor. If you take it the wrong way, or if you take too much, you can get very serious side effects. Do not stop taking this medicine unless your doctor tells you to, it may take several weeks or months before you see or feel the benefits. Do not smoke or drink alcohol. This may increase the risk of liver damage. This Endoxan N 1000 mg Injection should not be self-administered.
  

Uses of Endoxan N 1000 mg Injection

• • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma
  • Cutaneous T cell lymphoma (CTCL)
  • Acute myeloid leukaemia (AML)
  • Multiple myeloma
  • Chronic lymphocytic leukaemia (CLL)
  • Acute lymphoblastic leukaemia (ALL)
  • Retinoblastoma
  • Neuroblastomas
  • Ovarian cancer
  • Nephrotic syndrome
  • Chronic myelogenous leukaemia (CML)
    

Benefits of Endoxan N 1000 mg Injection

• Endoxan N 1000 mg Injection belongs to the group of medicines called alkylating agents used to treat malignant diseases such as Hodgkin's disease (cancer of the lymphatic system), mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma (cancer of plasma cells), Burkitt's lymphoma, leukaemia (blood cancer), neuroblastoma (cancer commonly found in the adrenal glands), retinoblastoma (eye cancer), adenocarcinoma of the ovary, mycosis fungoides, Ewing's sarcoma (cancer in and around the bones), small cell lung cancer, advanced/metastatic neuroblastoma and breast carcinoma. Endoxan N 1000 mg works by stopping or slowing the growth of cancer cells in the body. Thereby, Endoxan N 1000 mg helps treat cancer. Additionally, Endoxan N 1000 mg Injection is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Endoxan N 1000 mg Injection suppresses the body's immune system, thereby helping treat nephrotic syndrome.

Side Effects of Endoxan N 1000 mg Injection

• ​Endoxan N 1000 mg Injection may cause some side effects. If you experience any of these side effects contact your doctor as soon as possible. Your doctor may be able to suggest ways to manage or reduce the severity of these side effects.​

Most Common Side Effects of Endoxan N 1000 mg Injection

• • Bruising
  • Bleeding
  • Slow healing existing wounds
  • Mouth sores
  • Tiredness
  • Decrease in the amount of urine
  • Weakness

Common Side Effects of Endoxan N 1000 mg Injection

• • Leukopenia
  • Bladder bleeding
  • Serious Injection
  • Infertility
  • ​Nausea and vomiting
  • Bone marrow suppression
  • Hemorrhagic cystitis
  • Stomach ache
  • Darkening of the nails/skin
  • Diarrhoea
  • Thinning of hair
  • Alopecia (Hair Loss)
  • Change in texture and colour of the hair
  • Profound gonadotoxicity
  • Lethargy
    

How to Use Endoxan N 1000 mg Injection?

• Endoxan N 1000 mg Injection is administered intravenously (into a vein) by a health care professional, nurse or doctor in a medical facility. The frequency and dosage of Endoxan N 1000 mg Injection injection is decided by your health care professional or doctor. You should inform your health care, professional or doctor if you face any serious side effects. Do not self-administer Endoxan N 1000 mg.
  

How Endoxan N 1000 mg Injection Works?

• Endoxan N 1000 mg Injection contain an active ingredient called cyclophosphamide, which is an alkylating agent used in the treatment of cancer and certain autoimmune disorders. Endoxan N 1000 mg Injection acts by forming covalent bonds with DNA strands in rapidly dividing cells, including cancer cells. This process leads to the cross-linking of DNA strands, which interferes with their replication and transcription. Ultimately, the DNA damage caused by cyclophosphamide prevents cancer cells from growing and dividing. Additionally, Endoxan N 1000 mg Injection has immunosuppressive properties, which can be beneficial in certain autoimmune disorders. Endoxan N 1000 mg Injection suppresses the activity of the immune system by affecting lymphocytes, a type of white blood cell involved in immune responses. This immunosuppressive effect helps to reduce the overactive immune response associated with autoimmune conditions.

Safety Advices Endoxan N 1000 mg Injection

Driving

Unsafe

Endoxan N 1000 mg Injection may cause dizziness, fatigue, and difficulty concentrating and coordinating, which may affect your ability to drive a vehicle safely. It is important to follow your doctor's instructions and take necessary precautions such as avoiding driving a vehicle or operating heavy machinery if you suffer from the side effects of this Endoxan N 1000 mg.

Breastfeeding

Unsafe

It is not recommended to breastfeed while you are taking Endoxan N 1000 mg Injection. It is possible that Endoxan N 1000 mg Injection may pass into breast milk and cause harm to the baby. If you are breast-feeding and taking Endoxan N 1000 mg Injection, it is important that you talk to your doctor about the possible risks and benefits of continuing to breast-feed. Your doctor can help you make the best decision for you and for your baby.

Pregnancy

Unsafe

Use of Endoxan N 1000 mg Injection may be unsafe during pregnancy as animal studies indicate that it may harm the developing foetus. However, if you are pregnant or planning to become pregnant, it is important to talk to your doctor about the potential risks and benefits of taking Endoxan N 1000 mg during pregnancy. Your doctor will be able to help you make the best decision for you and your baby's health.

Kidney

Use with Caution

The use of Endoxan N 1000 mg Injection should be used with caution in patients with kidney disease. It is important for patients with kidney disease to monitor their kidney function closely while taking Endoxan N 1000 mg and to report any unusual symptoms or changes in kidney function to their doctor or health care professional. In patients with kidney disease, the dose of Endoxan N 1000 mg Injection may need to be adjusted.

Alcohol

Unsafe

Drinking alcohol while taking Endoxan N 1000 mg Injection is generally not recommended. This can increase the risk of liver injury, so avoid or limit alcohol while taking this medicine.

Liver

Use with Caution

Endoxan N 1000 mg Injection should be used with caution in patients with liver disease. It is important that patients with liver disease closely monitor liver function while taking Endoxan N 1000 mg and report any unusual symptoms or changes in liver function to their doctor. The dose of Endoxan N 1000 mg may need to be adjusted in patients with liver disease.