Introduction of Esentra 120 mg Injection

• Esentra 120 mg Injection contains Denosumab which belongs to the group of medicines called Monoclonal antibody. Esentra 120 mg Injection is used to treat adults with advanced cancer to prevent serious complications caused by bone metastasis (Ex. fractures, pressure on the spinal cord, radiation therapy or surgery). Esentra 120 mg Injection is also used to treat giant cell tumors of the bone, which cannot be treated by surgery, especially in adults whose bones have stopped growing. Symptoms include a visible mass, bone joints being affected (fracture, fluid buildup, limited movement, swelling and pain in the joints).
  
  Esentra 120 mg Injection may cause some common side effects of this medicine include pain in extremity, musculoskeletal pain, nerve pain, urinary tract infection, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.
  
  Esentra 120 mg Injection is not recommended for use in patients having hypocalcemia (low calcium levels in blood) and having unhealed wounds from oral surgery. Before receiving Esentra 120 mg Injection, inform your doctor if you have any problems with your mouth or teeth (poor dental health, gum disease etc.). Esentra 120 mg Injection is not recommended among women who are pregnant. Consult your doctor for advice before receiving Esentra 120 mg, if you are breast-feeding. Esentra 120 mg Injection is not recommended for children and adolescents under 18 years of age except for adolescents with giant cell tumors of the bone whose bones have stopped growing. The most common side effects of receiving Esentra 120 mg Injection are pain in the bones, joints, muscles, shortness of breath, diarrhea, hypophosphatemia (low phosphate level), excessive sweating.
  
  Esentra 120 mg Injection can be administered to you subcutaneously (under the skin) by a doctor or nurse. You should also take calcium and vitamin D supplements while being on treatment with Esentra 120 mg.Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
  

Uses of Esentra 120 mg Injection

• Esentra 120 mg Injection is used in the treatment of the following condition:

  • Osteoporosis
  • Bone loss due to hormonal therapy in breast or prostate cancer
  • Multiple myeloma (cancer affects plasma cells in the bone marrow)
  • Bone metastases (cancer that spreads to bone)
    

Benefits of Esentra 120 mg Injection

• Esentra 120 mg Injection binds to RANKL, a protein that is essential for the formation, function and survival of osteoclasts (the cells responsible for bone resorption). It inhibits osteoclast formation, function and survival, thereby decreasing bone resorption and increasing bone mass and strength of the bone. Along with this treatment, your doctor might ask you to make certain lifestyle changes such as maintaining good oral hygiene and quitting smoking. Your doctor may ask you to undergo a dental examination before you start the treatment.
  

Side Effects of Esentra 120 mg Injection

• Esentra 120 mg Injection has many adverse effects if it is used in the wrong way. But it varies from person to person and if you want, you can consult your doctor regarding these adverse effects.

Most Common Side Effects of Esentra 120 mg Injection

• • Arm or leg pain
  • Joint pain
  • Muscle or bone pain
  • Constipation,
  • Abdominal discomfort
  • Hair loss
  • Skin rash
  • Tingling, pain, or numbness that moves down your leg

Common Side Effects of Esentra 120 mg Injection

• • Upper respiratory tract infection
  • Frequent or painful urination, blood in urine, inability to hold urine
  • Musculoskeletal
  • Severe leg or joint pain

How to Use Esentra 120 mg Injection?

• ​Esentra 120 mg Injection can be administered to you subcutaneously (under the skin) by a doctor or nurse. You should also take calcium and vitamin D supplements while being on treatment with Esentra 120 mg.Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
  

How Esentra 120 mg Injection Works?

• Esentra 120 mg Injection works to slow down bone destruction caused by cancer spreading to the bone (bone metastasis) or by giant cell tumour of bone.
  

Safety Advices Esentra 120 mg Injection

Pregnancy

Unsafe

Esentra 120 mg Injection is not recommended for use in pregnant women and women of child-bearing potential not using contraception. Women should be advised not to become pregnant during and for at least 5 months after treatment with Esentra 120 mg. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Driving

Safe

Esentra 120 mg Injection has no or negligible influence on the ability to drive and use machines.

Breastfeeding

Unsafe

Esentra 120 mg Injection is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.

Alcohol

Unsafe

It is generally not recommended to drink alcohol while taking Esentra 120 mg Injection. It may increase the risk of liver damage. it is best to avoid alcohol or limit your alcohol consumption while taking any medication.

Kidney

Use with Caution

Esentra 120 mg Injection should be used with caution in patients having severe kidney problems. Patients with severe kidney impairment (creatinine clearance < 30 mL/min) or receiving dialysis are at greater risk of developing hypocalcaemia. Consult your doctor before receiving Esentra 120 mg.

Liver

Use with Caution

Esentra 120 mg Injection should be used with caution in patients with liver disease. It is important that patients with liver disease closely monitor liver function while taking Esentra 120 mg and report any unusual symptoms or changes in liver function to their doctor. The dose of Esentra 120 mg Injection may need to be adjusted in patients with liver disease.