Introduction of Irinotel 40 mg Injection

• ​Irinotel 40 mg Injection is a topoisomerase inhibitor indicated for the treatment of patients with advanced colorectal cancer. It may be in combination with 5-fluorouracil and folinic acid in patients without prior chemotherapy for advanced disease. Irinotel 40 mg Injection is used alone or in combination with other medicines indicated for the first-line treatment of patients with metastatic carcinoma of the colon or rectum.
  
  ​Irinotel 40 mg Injection is used with cetuximab is indicated for the treatment of patients with epidermal growth factor receptor (EGFR)-expressing, KRAS wild-type metastatic colorectal cancer, who had not received prior treatment for metastatic disease or after the failure of irinotecan-including cytotoxic therapy.
  
  ​Irinotel 40 mg Injection may cause some common side effects of this medicine including fatigue, nausea, vomiting, weakness, and hair loss. Irinotel 40 mg Injection may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhoea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
  
  ​Before taking Irinotel 40 mg Injection, tell your doctor if you have chronic inflammatory bowel disease or bowel obstruction, severe bone marrow failure, and if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. Irinotel 40 mg Injection is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
  
  ​Irinotel 40 mg Injection is administered by a healthcare professional or nurse in a hospital or clinic setting. The specific dosing and administration of Irinotel 40 mg Injection will depend on the clinical condition of the patient's age and medical history and other factors. Kindly do not self-administer.​
  

Uses of Irinotel 40 mg Injection

• • Treatment of colon and rectum cancer
    

Benefits of Irinotel 40 mg Injection

• ​Treatment of colon and rectum cancer: Cancer of the colon and rectum, also known as colorectal cancer (CRC) or bowel cancer, is the development of cancer from two parts of the large intestine, namely, the colon or rectum. In this type of cancer, the person may notice symptoms such as blood in the stool, a change in bowel movements, weight loss, and fatigue. Irinotel 40 mg Injection treats and also lowers the risk of developing further cancerous growths (polyps) and bowel cancer. It kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. Avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.​
  

Side Effects of Irinotel 40 mg Injection

• ​​​​​Like all medications, Irinotel 40 mg Injection can cause side effects but do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.​​

Most Common Side Effects of Irinotel 40 mg Injection

• • Nausea
  • Vomiting
  • Constipation
  • Fever
  • Infection
  • Pain

Common Side Effects of Irinotel 40 mg Injection

• • Diarrhea
  • Kidney Impairment
  • Lung Problems
  • Low blood count

How to Use Irinotel 40 mg Injection?

• ​Irinotel 40 mg Injection is administered by a qualified doctor or nurse at a hospital or clinical setting. It is given intravenously and is usually given as part of a combination chemotherapy regimen. The specific treatment plan and dosage will depend on the type and stage of the cancer being treated, as well as other individual factors determined by the healthcare provider.​
  

How Irinotel 40 mg Injection Works?

• ​Irinotel 40 mg Injection is a chemotherapy medication used to treat certain types of cancer, including colorectal cancer. It belongs to a class of drugs known as topoisomerase I inhibitors. Irinotel 40 mg specifically targets and inhibits an enzyme called topoisomerase I, which plays a crucial role in DNA replication and repair. This slows the growth of cancer cells and eventually kills them.​

Safety Advices Irinotel 40 mg Injection

Alcohol

Unsafe

It is generally not recommended to drink alcohol while taking Irinotel 40 mg Injection. It may increase the risk of liver damage. it is best to avoid alcohol or limit your alcohol consumption while taking any medication.

Driving

Use with Caution

Irinotel 40 mg Injection has a moderate influence on the ability to drive and use machines. Patients should be warned about the potential for dizziness or visual disturbances which may occur within 24 hours following the administration of Irinotel 40 mg and advised not to drive or operate machinery if these symptoms occur.

Liver

Use with Caution

Irinotel 40 mg Injection should be used with caution in patients with liver disease. It is important that patients with liver disease closely monitor liver function while taking Irinotel 40 mg and report any unusual symptoms or changes in liver function to their doctor. The dose of Irinotel 40 mg Injection may need to be adjusted in patients with liver disease.

Pregnancy

Unsafe

There are limited data on the use of irinotecan in pregnant women. Irinotel 40 mg Injection has been shown to be embryotoxic and teratogenic in animals. Therefore, based on results from animal studies and the mechanism of action of Irinotel 40 mg, Irinotel 40 mg Injection should not be used during pregnancy unless clearly necessary. Women of childbearing potential should not be started on Irinotel 40 mg Injection until pregnancy is excluded. Pregnancy should be avoided if either partner is receiving Irinotel 40 mg Injection.

Breastfeeding

Unsafe

The available data are limited but suggested that Irinotel 40 mg Injection and its metabolite are excreted in human milk. Consequently, because of the potential for adverse reactions in nursing infants, breastfeeding should be discontinued for the duration of Irinotel 40 mg therapy.

Kidney

Use with Caution

Irinotel 40 mg Injection should be used with caution in patients with kidney disease. It is important that patients with kidney disease closely monitor kidney function while taking Irinotel 40 mg and report any unusual symptoms or changes in kidney function to their doctor. Irinotel 40 mg Injection is not recommended for use in patients on dialysis.